Saw Palmetto is an herbal extract taken in the fruit Of those Dwarf tree discovered largely in Florida in the United States.
What’s Saw Palmetto Used for Medicine?
It is most notable use by far has been for the lower Urinary tract infections associated with Benign Prostatic Hypertrophy (BPH).
But this herbal remedy hasn’t yet been welcomed with open arms from mainstream Western medicine, that elect rather to focus on
pharmaceutical and surgical remedies for treatment for an enlarged prostate.
Saw Palmetto Pills for Prostate
A Current systemic inspection Estimated the incidence of symptomatic BPH rises from 14.8percent in males aged 40 to 36.8percent in
men aged 80 and over
The motives causing the Prostate to expand are still poorly known. DHT is derived from testosterone in specific tissues such as
the prostate gland through the activity of 5α-reductase.
Medication for the drug-related adverse Effects related to α-blockers (e.g., postural hypotension and retrograde ejaculation) and with 5-ARIs (e.g.,
handicap of erection)
phytotherapy including Infusion of the fruit from saw palmetto (Serenoa repens), the American dwarf palm tree has been used.
Native Americans were Known to use the fruit of saw palmetto to treat prostate and reproductive system problems (Suzuki et al.,
2009). SPE Is Usually used to treat BPH in Europe
Disparity in makeup Of SPE may contribute to heterogeneity in efficacy (Habib and Wyllie, 2004). Various products derived from
precisely the exact same plant can have distinct action due to differences in the makeup of bioactive elements in the plant
extracts (Novara et al., 2016). Many SPE products were found to possess significantly different comparative contents of putative
active elements, fatty acids and phytosterols
Permixon contained the Highest content (>80%) of fatty acids among 14 products offered in Europe (Habib and Wyllie, 2004).
Permixon also showed the highest efficacy in inhibition of 5α-reductase (Scaglione et al., 2012). Regularly, clinical studies with
Permixon have produced reproducible results of improvement of urinary symptoms
These data suggested that Different manufacturers of SPE may show marked variation in articles. Therefore, standardization of SPE
formulation, and management of the content of active elements in SPE may be critical to achieving consistent effectiveness of SPE
and recommendations for its use in prevention and treatment of BPH
Lipidosterolic extract of saw palmetto, is the most studied type of SPE and research with Permixon have produced relatively
consistent beneficial impacts on LUTS in preclinical and clinical levels.
Saw Palmetto pills for hair loss
A systematic overview of Saw Palmetto studied for alopecia included a study in which 38% of individuals in the Saw Palmetto cohort
had an increase in hair growth, mainly on the vertex. This was compared to Finasteride, in contrast to which Saw Palmetto had an
inferior percentage, but it was useful nonetheless.
Besides systemic Therapy, SP has also been analyzed as a topical agent. A study evaluating the hair growth impact of 3.3 mL
topical SP serum employed for 4 weeks and 2 mL cream for 24 weeks, in 50 men with AGA, demonstrated increased terminal and average
hair counts at 12 and 24 months . Although systemic SP hasn’t demonstrated superiority to conventional systemic treatments, it
does have clinical advantages and can be an attractive alternative remedy for men AGA patients that are uninterested in oral
Side effects of saw palmetto pills
In general, saw palmetto extracts are well tolerated in men with BPH. There’s agreement that negative effects of saw palmetto
extracts are few and mild, which their incidences Aren’t considerably different in comparison with placebo
The Most Often reported adverse events are More serious adverse events like death and cerebral hemorrhage are reported in isolated
case reports and data from spontaneous reporting schemes, but causality remains questionable. No drug interactions have been
reported. Presently available data suggest that S. repens is well tolerated by most consumers and is not associated with severe
Saw Palmetto pills advantages
The exact mechanics of Activity of SPE are unknown in alleviating LUTS associated with BPH. Suggested mechanisms include
anti-androgenic, pro-apoptotic, and anti inflammatory effects
The bioactive components Of SPE are regarded as fatty acids and phytosterols (Table 1
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859144/table/Tab1/]). The composition of the various manufacturers of saw palmetto
varies depending on extraction methods, source of this plant, and additional ingredients (Penugonda and Lindshield, 2013). The
content of free fatty acids was found to range from 40.7 to 80.7percent (Table 1
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859144/table/Tab1/]) from 14 SPE extracts commercially available for the treatment
Fatty acids are the major Constituents of SPE. The main fatty acids in SPE revealed α1-adrenergic receptor-binding activity and
inhibitory effects on 5α-reductase (Abe et al., 2009a; 2009b), suggesting that fatty acids at SPE contribute to relieving BPH
symptoms via comfort of muscle tone and inhibition of testosterone metabolism.
Phytosterols are comparatively Studies have suggested that phytosterols can be beneficial in BPH therapy due to their anti
inflammatory and anti-microbial effects
In Summary, saw Palmetto extract has curative potential. However, effectiveness of SPE has been found to be inconsistent, at least
partially because of lack of standardization of the SPE formula. Free fatty acids such as lauric acid, the main components of SPE,
have been demonstrated to be most effective in inhibition of both 5α-reductase and phytosterol (β-sitosterol), small constituents
of SPE, has been found to effectively reduce prostatic inflammation. Multiple rather than single mechanisms may be involved in the
beneficial effects of SPE in BPH treatment. Therefore, it’s very important to standardize SPE products for consistent efficacy and
to enable recommendations for SPE use in prevention and treatment of BPH.
1 study even Revealed that Saw Palmetto may be able to be utilized to prevent or cure erectile dysfunction. However, this is a rat
study, therefore human information in this respect remains incomplete.
Saw Palmetto for Breast Enlargement
This was promoted in some circles because of the On the other hand, the literature has not supported this claim thus far.
As Soon as You parse out the literature, It Seems that the Only form of Saw Palmetto which has shown any impact has especially
Been the liquid extract form. In Europe, this is the Promixon product. And now In the Unites States, the sole Saw Palmetto product
approved by the USP is Flowmentum. Thus, make sure to look for the liquid extract form of Saw Palmetto, instead of the numerous
powder infusion products out on the market. Along with its low side effect profile, the liquid extract form of Saw Palmetto should
Make for a worthwhile attempt when combatting the urinary symptoms of BPH. Heck, it Shows benefit for hair regrowth as well, but
that is a portion of another discussion.